Ammonium pyrrolidinedithiocarbamate, approx.99%

Ammonium pyrrolidinedithiocarbamate, approx.99%

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Application


Ammonium pyrrolidinedithiocarbamate has been used:to inhibit nuclear factor ?B (NF-?B) mobilization and TNF (tumor necrosis factor) production in human monocytesto reduce neutrophil activity in ratsto prevent Ca2+ influx in adriamycin (ADR)-treated podocytesto abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells


Biochem/physiol Actions


Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.


General description


Ammonium pyrrolidinedithiocarbamate is a nuclear factor ?B (NF-?B) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.


Packaging


1, 5, 100 g in glass bottle

Quality Level200
mp153-155 °C (lit.)
InChI keyMDDIUTVUBYEEEM-UHFFFAOYSA-N
InChI1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
ManufacturerSIGMA-ALDRICH
Formpowder
Assay~99%

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