Acetazolamide, >=99%, powder

Acetazolamide, >=99%, powder

Stock Code: 3577617
Manufacturer Part No: A6011-25G
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Application


Carbonic anhydrase inhibitor; increases cerebral blood flow.


Acetazolamide has been used:to study its protective effect on steatotic liver grafts against cold ischemia reperfusion injury{49)to determine its ability to bind isolated porcine retinal pigment epithelium (RPE) melanin by cassette dosing and rapid equilibrium dialysis insertsto validate the in vitro gastrulation model of P19C5 stem cells for developmental toxicity screening assaysto study its inhibitory effect on melanogenesis through enzyme kinetic, in vitro, in vivo and in silico analyses in zebrafish and in A375 human melanoma cells


Biochem/physiol Actions


Inhibits water permeability of membranes by interacting with aquaporins


Acetazolamide is a member of sulfonamide drug family. It as an ability to inhibit the activity of carbonic anhydrase. It rapidly increases cerebral blood flow (CBF) and is used as an investigative tool in CBF studies. Acetazolamide acts as a therapeutic agent for epilepsy, glaucoma and pseudotumor cerebri.


Other Notes


Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A6011.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

mp258-259 °C
InChI keyBZKPWHYZMXOIDC-UHFFFAOYSA-N
InChI1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥99%

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