4-Methylpyrazole hydrochloride, alcohol dehydrogenase inhibitor

Stock Code: 3577840
Manufacturer Part No: M1387-100MG

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Descriptions

Application

Useful as an antidote in methanol and ethylene glycol poisoning.

4-Methylpyrazole hydrochloride has been used: as a cytochrome P450 2E1 inhibitoras cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cellsto inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells

Biochem/physiol Actions

4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.

Alcohol dehydrogenase inhibitor

Packaging

100, 500 mg in poly bottle

1 g in poly bottle

Specifications

Quality Level	200
mp	157-159 °C
InChI key	PUCXJHNDMYZOHG-UHFFFAOYSA-N
InChI	1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥95%