3-Isobutyl-1-methylxanthine, >=99% (HPLC), powder

3-Isobutyl-1-methylxanthine, >=99% (HPLC), powder

Stock Code: 3577812
Manufacturer Part No: I5879-100MG
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£55.58 (exc VAT) per 100MG
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Application


3-Isobutyl-1-methylxanthine has been used:in the differentiation of mesenchymal stem cells (MSC)as a culture medium supplement for inducing adipogenic differentiationas a supplement in Krebs-Ringer buffer with HEPES (KRBH) solution for inducing glucose-stimulated insulin secretion (GSIS)in the characterization of adipose-derived mesenchymal stem cellsin cyclic adenosine monophosphate (cAMP) assayin phosphodiesterase (PDE) inhibition


Biochem/physiol Actions


The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 µM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.


General description


3-isobutyl-1-methylxanthine/IBMX is a non-selective, non-specific inhibitor of cAMP and cGMP phosphodiesterases. IBMX can induce melanogenesis, and can be used as a positive control in melanogenesis research. In oocyte research, IBMX assists in maintaining the germinal vesicle (GV) arrest of prophase I oocytes.


Packaging


100 mg in poly bottle


1, 5 g in poly bottle


250 mg in poly tube

Colourwhite to off-white
Quality Level200
mp200-201 °C (lit.)
InChI keyAPIXJSLKIYYUKG-UHFFFAOYSA-N
InChI1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Solubilityethanol: 10 mg/mL; DMSO: 1 M (with gentle warming)
Formpowder
Assay≥99% (HPLC)

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