(+/-)-Bay K8644, calcium channel agonist
Application
(±)-Bay K8644 has been used as an agonist for voltage sensitive calcium channels (VSCCs) in interneurons, L-type calcium channel (LTCC) in human embryonic kidney 293 cells and viscerofugal neurons.
Biochem/physiol Actions
(±)-Bay K8644 is a 1,4-dihydropyridine (DHP) derivative and an agonist for L-type Ca2+ channels. However, it?s enantiomers (-)-BAY k8644 and (+)-BAY k8644 have opposing functionality with respect to Ca2+ channels as high-potency agonist and low-potency antagonist, respectively. (±)-Bay K8644 increases influx of Ca2+ specifically at voltage-gated calcium channels. It constricts blood vessels and heart contraction.
Increases influx of Ca2+ specifically at voltage-gated calcium channels.
Packaging
5, 25 mg in glass bottle
| Colour | yellow to dark yellow |
|---|---|
| Quality Level | 100 |
| mp | 168-170 °C |
| InChI key | ZFLWDHHVRRZMEI-UHFFFAOYSA-N |
| InChI | 1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3 |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥97.5% (HPLC) |
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