(+)-Tubocurarine chloride pentahydrate, >=97.0% (TLC)
Application
(+)-Tubocurarine chloride pentahydrate has been used:as an acetylcholine receptor antagonist in synapse blocking experiment to study its effect on neuromuscular junction formation (NMJ) formation in a co-culture system of human skeletal muscles and human stem cell-derived motoneuronsto induce paralysis in zebrafish larvae to study whole-brain imaging of seizures by two-photon light-sheet microscopyto block NMJ to study its role in myotube contraction
Biochem/physiol Actions
(+)-Tubocurarine chloride pentahydrate serves as a neuromuscular blocker.
Classical competitive antagonist of the nicotinic acetylcholine receptor. Structure-activity relationships and conformational studies for tubocurarine binding at the nicotinic AChR.
Packaging
1 g in poly tube
250 mg in poly bottle
| mp | 275-280 °C (dec.) (lit.) |
|---|---|
| InChI key | WMIZITXEJNQAQK-GGDSLZADSA-N |
| InChI | 1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31 |
| Manufacturer | SIGMA-ALDRICH |
| Impurities | ~12% water |
| Form | powder |
| Assay | ≥97.0% (TLC) |
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