Sodium cholate hydrate, suitable for cell culture, BioReagent

Sodium cholate hydrate, suitable for cell culture, BioReagent

Stock Code: 3571495
Manufacturer Part No: C9282-100G
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£378.75 (exc VAT) per 100G
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Application


Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-A-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes.


Sodium cholate hydrate has been used:as a bile acid to induce bile acid-responsive (BEAR) transcription system, as a component of Campylobacter defined broth (CDB) to test its effect on stress response in Campylobacter jejuni{52to test its sensitivity towards the bile acid sensor


Biochem/physiol Actions


Reduction in 12-? hydroxylase activity leads to low levels of cholic acid in liver disease.


General description


Cholate is a primary bile acid produced from cholesterol in the liver. It is an anionic detergent synthesized from cholesterol in the presence of sterol 12?-hydroxylase (CYP8B1).


Packaging


25, 100 g in poly bottle

Pack100G
InChI keyMUVVIYFKOVLQHL-RCVKHMDESA-M
ManufacturerSIGMA-ALDRICH
Further Infoanionic
Formpowder
Assay≥99.0% (HPLC)

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