Glucagon, synthetic, powder, cell culture tested

Glucagon, synthetic, powder, cell culture tested

Amino Acid Sequence

His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr

Application

Glucagon has been used:in the stimulation of human primary hepatocytes for cyclic adenosine monophosphate (cAMP) productionfor measuring glucagon response in miceto induce gluconeogenic stimuli in primary hepatocytes

Biochem/physiol Actions

Glucagon functions to elevate glucose by activating GCGR in liver mediating the glucose circulation in blood. The hyperglucagonemia elevated levels of glucagon is observed in diabetes and in nonalcoholic fatty liver disease, post gastric bypass surgery and glucagon based tumors.

Components

H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl

General description

Glucagon is a peptide hormone of 29 amino acids secreted by alpha cells in the pancreas. Its release is controlled by hypothalamus when glucose levels in the blood decreases. The C-terminal region of glucagon is crucial for receptor binding.

Other Notes

This product is a chemically synthesized glucagon qualified for use in cell culture applications.

Packaging

1, 5, 25 mg in glass bottle

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

No detailed specifications are available for this product.

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Code Description Quality Level Pack InChI key InChI Manufacturer Form Assay Price Quantity
3571714 Glucagon, synthetic, powder, cell culture tested 200 1MG RKGLLHCSSVJTAN-YYICOITRSA-N 1S/C153H225N43O49S.ClH/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64- SIGMA-ALDRICH powder ≥95% (HPLC)
£170.00 (exc VAT) per 1MG
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3571715 Glucagon, synthetic, powder, cell culture tested 200 25MG RKGLLHCSSVJTAN-YYICOITRSA-N 1S/C153H225N43O49S.ClH/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64- SIGMA-ALDRICH powder ≥95% (HPLC)
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3571716 Glucagon, synthetic, powder, cell culture tested 200 5MG RKGLLHCSSVJTAN-YYICOITRSA-N 1S/C153H225N43O49S.ClH/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64- SIGMA-ALDRICH powder ≥95% (HPLC)
£596.25 (exc VAT) per 5MG
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