N-Butyldeoxynojirimycin, film (dried in situ)
Application
N-Butyldeoxynojirimycin has been used:in the inhibition of glycolipid synthesis in neuroblastoma cellsin the inhibition the ceramide-specific glycosyltransferase in hepatocytesin the inhibition of ?-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.
Biochem/physiol Actions
N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and ?-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.
α-glucosidase Inhibitor
General description
N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.
Packaging
1, 5 mg in glass bottle
| Quality Level | 200 |
|---|---|
| InChI key | UQRORFVVSGFNRO-UTINFBMNSA-N |
| InChI | 1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | water: 9.80-10.20 mg/mL, clear, colorless |
| Form | film (dried in situ) |
| Assay | ≥98% (TLC) |
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