Methotrexate hydrate, powder, BioReagent, suitable for cell culture, >=98% (HPLC)

Methotrexate hydrate, powder, BioReagent, suitable for cell culture, >=98% (HPLC)

Stock Code: 3571984
Manufacturer Part No: M8407-500MG
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Application


Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.


Methotrexate hydrate has been used: as a dihydrofolate (DHFR)inhibitor in sphere forming assay cultureas a component of dulbecco? modified Eagle?s medium (DMEM) for selection of transfected cells in viability and co-culture assays


Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.


Biochem/physiol Actions


Methotrexate used to inhibit dihyrofolate reductase and select for DHFR overexpresssion.


Methotrexate is a folic acid antagonist.

Pack500MG
InChI keyFPJYMUQSRFJSEW-ZOWNYOTGSA-N
InChI1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30
ManufacturerSIGMA-ALDRICH
Product LineBioReagent
Formpowder
Assay≥98% (HPLC)

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