Methotrexate hydrate, powder, BioReagent, suitable for cell culture, >=98% (HPLC)
Application
Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Methotrexate hydrate has been used: as a dihydrofolate (DHFR)inhibitor in sphere forming assay cultureas a component of dulbecco? modified Eagle?s medium (DMEM) for selection of transfected cells in viability and co-culture assays
Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.
Biochem/physiol Actions
Methotrexate used to inhibit dihyrofolate reductase and select for DHFR overexpresssion.
Methotrexate is a folic acid antagonist.
| Pack | 500MG |
|---|---|
| InChI key | FPJYMUQSRFJSEW-ZOWNYOTGSA-N |
| InChI | 1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30 |
| Manufacturer | SIGMA-ALDRICH |
| Product Line | BioReagent |
| Form | powder |
| Assay | ≥98% (HPLC) |
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