Glucagon, synthetic, powder, cell culture tested

Glucagon, synthetic, powder, cell culture tested

Stock Code: 3571716
Manufacturer Part No: G2044-5MG
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Amino Acid Sequence


His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr


Application


Glucagon has been used:in the stimulation of human primary hepatocytes for cyclic adenosine monophosphate (cAMP) productionfor measuring glucagon response in miceto induce gluconeogenic stimuli in primary hepatocytes


Biochem/physiol Actions


Glucagon functions to elevate glucose by activating GCGR in liver mediating the glucose circulation in blood. The hyperglucagonemia elevated levels of glucagon is observed in diabetes and in nonalcoholic fatty liver disease, post gastric bypass surgery and glucagon based tumors.


Components


H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl


General description


Glucagon is a peptide hormone of 29 amino acids secreted by alpha cells in the pancreas. Its release is controlled by hypothalamus when glucose levels in the blood decreases. The C-terminal region of glucagon is crucial for receptor binding.


Other Notes


This product is a chemically synthesized glucagon qualified for use in cell culture applications.


Packaging


1, 5, 25 mg in glass bottle


Physical form


powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Quality Level200
Pack5MG
InChI keyRKGLLHCSSVJTAN-YYICOITRSA-N
InChI1S/C153H225N43O49S.ClH/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥95% (HPLC)

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