Conduritol B epoxide,
Application
Conduritol B epoxide has been used as an inhibitor of GBA1 to discriminate between acid ?-glucosidase (GBA1) and non-lysosomal ?-glucosidase (GBA2) activity in ?-glucosidase activity assay. It has also been used as a selective glucocerebrosidase (GCase) inhibitor.
Biochem/physiol Actions
Conduritol B epoxide(CBE)is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson?s disease (PD).
β-Glucosidase inhibitor
General description
Conduritol B epoxide(CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.
Packaging
5, 25 mg in glass insert
| Quality Level | 100 |
|---|---|
| InChI key | ZHMWOVGZCINIHW-UHFFFAOYSA-N |
| InChI | 1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | water: 20 mg/mL, clear, colorless to faintly yellow |
| Form | powder |
| Assay | ≥95% (TLC) |
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