Aminopterin, powder, BioReagent, suitable for cell culture

Aminopterin, powder, BioReagent, suitable for cell culture

Stock Code: 3571314
Manufacturer Part No: A3411-25MG
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£192.50 (exc VAT) per 25MG
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Application


Aminopterin has been used in the production of anti- neurogranin antibodies.


Biochem/physiol Actions


Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.


Aminopterin is found to inhibit growth, embryogenesis and has toxic effects in mice models. It serves as a abortifacient. Aminopterin is known to reduce the effects of acute leukemia in children.


Linkage


More potent, but more toxic, than methotrexate.

Colouryellow
Pack25MG
InChI keyTVZGACDUOSZQKY-LBPRGKRZSA-N
InChI1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥97%

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