Acetylcholine chloride, suitable for cell culture

Acetylcholine chloride, suitable for cell culture

Stock Code: 3571296
Manufacturer Part No: A2661-25G
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Application


Acetylcholine chloride has been used in the preparation of acetylcholine, that is used as a common vehicle for iontophoresis of acetylcholine (ACh). It has also been used to treat aNS-1 derived neurons for cAMP (cyclic adenosine monophosphate) assay and also used to check their ability to influence G protein-coupled receptors (GPCRs).


Biochem/physiol Actions


Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Quality Level400
Pack25G
mp146-150 °C (lit.)
InChI keyJUGOREOARAHOCO-UHFFFAOYSA-M
InChI1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
ManufacturerSIGMA-ALDRICH
Formpowder
Assay~99%

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