3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester, >=95%, powder
Application
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.It has been used for antibody conjugation and as a protein cross-linker.
General description
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.
Packaging
5 mg in glass bottle
25, 100 mg in poly bottle
| Quality Level | 200 |
|---|---|
| mp | 84-86 °C (lit.) |
| InChI key | JWDFQMWEFLOOED-UHFFFAOYSA-N |
| InChI | 1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2 |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥95% |
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