Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride, kallikrein substrate

Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride, kallikrein substrate

Stock Code: 3578238
Manufacturer Part No: C9521-100MG
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Application


Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride has been used:as a fluorogenic substrate in actinidin inhibition assayas a kallikrein substrateas a trypsin substrate for fluorometric assayas a cathepsin-L substrate


Biochem/physiol Actions


Z-Phe-Arg 7-amido-4-methylcoumarin (Z-FR-AMC) proteolytic lysis by proteases leads to the liberation of AMC resulting in increased fluorescence in the enzymatic reaction.


General description


Z-Phe-Arg 7-amido-4-methylcoumarin (Z-FR-AMC) is a peptidomimetic substrate for papainand other enzymes such as cathepsin K. It is also a fluorogenic synthetic peptide for the enzymes cathepsins L and B.


Packaging


100 mg in glass bottle


25 mg in glass insert


Substrates


A fluorogenic substrate for plasma kallikrein.

Quality Level100
InChI keyZZGDDBWFXDMARY-UHFFFAOYSA-N
InChI1S/C33H36N6O6/c1-21-17-29(40)45-28-19-24(14-15-25(21)28)37-30(41)26(13-8-16-36-32(34)35)38-31(42)27(18-22-9-4-2-5-10-22)39-33(43)44-20-23-11-6-3-7-12-23/h2-7,9
ManufacturerSIGMA-ALDRICH
Solubilitymethanol: 20 mg/mL, clear, colorless
Formpowder
Assay≥95% (HPLC)

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