L-alpha-Hydroxyglutaric acid disodium salt, >=98.0% (GC)

Stock Code: 3578024
Manufacturer Part No: 90790-10MG

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Descriptions

Application

L-?-Hydroxyglutaric acid disodium salt is suitable for use in collection buffer for increased recovery of hypoxia-inducible factor-1 ? (HIF-1?), a marker of hypoxia in human tumors. It is also suitable for the radiolabeled 5mC-5hmC conversion assay to study the effect of 2-HG on the TET family of methyl hydroxylases.

Biochem/physiol Actions

L-alpha-Hydroxyglutaric acid accumulates as a result of a rare defect in L-2-HG dehydogenase, leading to the metabolic disorder L-2-hydroxyglutaric aciduria (L-2HGA). L-2HGA is associated with neuronal defects, leukodystrophy and linked to an increased risk of brain tumors.

General description

Glutamic acid is metabolized to ?-Hydroxyglutaric acid in an NAD-dependent manner by cell-free extracts of Peptococcus aerogenes. It is formed as an intermediate during glyoxylic acid metabolism in bacteria.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Specifications

Quality Level	100
InChI key	DZHFTEDSQFPDPP-QTNFYWBSSA-L
InChI	1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
Manufacturer	SIGMA-ALDRICH
Impurities	≤6.0% water
Form	powder or crystals
Assay	≥98.0% (GC)