Farnesyl pyrophosphate ammonium salt, methanol:ammonia solution, >=95% (TLC)

Farnesyl pyrophosphate ammonium salt, methanol:ammonia solution, >=95% (TLC)

Stock Code: 3578283
Manufacturer Part No: F6892-1VL
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Application


Farnesyl pyrophosphate ammonium salt has been used: as a prenylation agonist in human osteogenic sarcoma cells in collagen-based cell invasion assays in the prenylation of the hepatocyte growth factor (HGF) in human umbilical vein endothelial cells (HUVECs) as a substrate in prenyltransferases assay in diatom Haslea ostrearia


Biochem/physiol Actions


Farnesyl pyrophosphate (FPP) is the precursor for the biosynthesis of cholesterol, ubiquinone and dolicol. It is part of the intracellular mevalonate pathway. FPP is essential for cell survival and is used for prenylation of several low molecular mass G proteins, including Ras. Inhibition of prenylation results in loss of oncogenic potential of Ras proteins. Inhibition of prenylation may serve as therapeutic potential for management of synaptic plasticity and Alzheimer?s disease.


General description


Farnesyl pyrophosphate is a 15-carbon isoprenoid synthesized from geranyl pyrophosphate (GPP) by the action of enzyme farnesyl pyrophosphate synthase (FPPS).


Packaging


5 vials in poly bottle


1 vial in poly bottle


Physical form


Solution in methanol: 10mM aqueous NH4OH (7:3)Actual concentration given on label

Quality Level100
InChI keyVWFJDQUYCIWHTN-YFVJMOTDSA-N
InChI1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
ManufacturerSIGMA-ALDRICH
Formmethanol:ammonia solution
Assay≥95% (TLC)

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