5-Fluoroorotic acid hydrate, >=98%
Application
5-Fluoroorotic acid hydrate has also been used as a counter-selection agent to screen L. lactis (multi) peptidase knockout mutants and C. albicans. It has been used in synthesis of 5-fluoroorotidine 5?-monophosphate (FOMP).
Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.
Biochem/physiol Actions
5-Fluoroorotic acid is a selective inhibitor of rRNA synthesis in mammals.
Packaging
1 g in poly bottle
50 mg in glass insert
250 mg in poly bottle
| Quality Level | 200 |
|---|---|
| mp | 278 °C (dec.) (lit.) |
| InChI key | LODRRYMGPWQCTR-UHFFFAOYSA-N |
| InChI | 1S/C5H3FN2O4.H2O/c6-1-2(4(10)11)7-5(12)8-3(1)9;/h(H,10,11)(H2,7,8,9,12);1H2 |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥98% |
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