5-Aminosalicylic acid, >=99%

Stock Code: 3578065
Manufacturer Part No: A3537-100G

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Descriptions

Application

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

5-Aminosalicylic acid (5-ASA) has been used: to synthesize 5-formyl-aminosalicylate-inulin to quantify its release during in vitro digestion and fermentation and compare the in vitro fermentation properties of the conjugated inulin to native inulinin cell adhesion assay to study its effects on E-cadherin glycosylation and membranous turnoverto evaluate its effects on the neutrophilic inflammation index (NII) phenotype to study the effectiveness of the high cholesterol diet-gut inflammation(HCD-GI) platform

Biochem/physiol Actions

5-Aminosalicylic acid (5-ASA) is a first-line medicine, used to treat inflammatory bowel diseases like ulcerative colitis (UC). It has a high-efficiency rate in maintenance and induction of remission. 5-ASA is an active component of sulfasalazine and also consists of the carbohydrate polymer, inulin. It might exhibit anti-oxidant activity to lessen tissue injury. 5-ASA is vital for the prevention of T cell activation and proliferation. It negatively regulates cyclooxygenase and lipoxygenase pathways and lowers the formation of prostaglandins and leukotrienes. 5-ASA stimulates the membranous expression of E-cadherin and boosts intercellular adhesion.

Packaging

25, 100 g in poly bottle

Specifications

Colour	off-white to gray
Quality Level	200
mp	275-280 °C (dec.) (lit.)
InChI key	KBOPZPXVLCULAV-UHFFFAOYSA-N
InChI	1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥99%