4-Methylumbelliferone sodium salt, >=98% (HPLC), crystalline
Application
4-Methylumbelliferone sodium salt has been used:as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liveras a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate actionin cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer
Biochem/physiol Actions
4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5?-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.
General description
4-methylumbelliferone (4-MU) is a coumarin derivative.
| Colour | yellow |
|---|---|
| Quality Level | 200 |
| InChI key | JGMQHDNPUCPRQE-UHFFFAOYSA-M |
| InChI | 1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1 |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | water: 50 mg/mL |
| Form | crystalline |
| Assay | ≥98% (HPLC) |
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