4-Methylumbelliferone sodium salt, >=98% (HPLC), crystalline

4-Methylumbelliferone sodium salt, >=98% (HPLC), crystalline

Stock Code: 3578413
Manufacturer Part No: M1508-100G
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Application


4-Methylumbelliferone sodium salt has been used:as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liveras a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate actionin cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer


Biochem/physiol Actions


4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5?-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.


General description


4-methylumbelliferone (4-MU) is a coumarin derivative.

Colouryellow
Quality Level200
InChI keyJGMQHDNPUCPRQE-UHFFFAOYSA-M
InChI1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
ManufacturerSIGMA-ALDRICH
Solubilitywater: 50 mg/mL
Formcrystalline
Assay≥98% (HPLC)

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