Cyclosporin A, from Tolypocladium inflatum, BioReagent, for molecular biology, >=95%

Cyclosporin A, from Tolypocladium inflatum, BioReagent, for molecular biology, >=95%

Stock Code: 3581838
Manufacturer Part No: C1832-10MG
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£848.25 (exc VAT) per 10MG
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Application


Cyclosporin A was suitable for: Using in in vivo Neovascularization Assay, to subcutaneously inject the mice daily for suppressing the immune response.Measuring the multiple drug resistance transporter activity in putative cancer stem/progenitor cells.mRNA transcription studiesanalytical standard


Biochem/physiol Actions


A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.


Cyclosporin A has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+ - and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity. It was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes.


General description


Chemical structure: peptide


Cyclosporin A is a fungal metabolite with immunosuppressive properties. Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes.


Packaging


5, 10 mg in glass bottle

InChI keyPMATZTZNYRCHOR-CGLBZJNRSA-N
InChI1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥95%

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