2,3-Dideoxycytidine, >=98% (HPLC)
Application
2?,3?-Dideoxycytidine is used:as a DNA chain-terminating nucleotide for DNA sequencing methods based on the Sanger chain-termination methodas a nucleoside reverse transcriptase inhibitor (NRTI) to study its effects on the development of mechanical allodynia in aging miceas a mitochondrial DNA (mtDNA) replication inhibitor to inhibit the activation of cGAS-STING pathway and study its effects on signaling protein-stimulator of interferon genes (STING), cyclic GMP-AMP synthase (cGAS), and phospho-interferon regulator factor 3 (p-IRF3) expression in mouse hippocampal and microglial cellsas an NRTI inhibitor to study its effects on the drug induced-mitochondrial toxicity in Caenorhabditis elegans
Biochem/physiol Actions
2?,3?-Dideoxycytidine (ddC), is an ionic compound and a nucleoside analog. It acts as a nucleoside reverse transcriptase inhibitor and exhibits therapeutic effects against human immunodeficiency virus (HIV) infection. 2?,3?-Dideoxycytidine possesses anti-adenovirus activity and inhibits the adenovirus polymerase.
Packaging
100, 250, 500 mg in poly bottle
| Colour | colorless |
|---|---|
| Quality Level | 200 |
| mp | 217-218 °C (lit.) |
| InChI key | WREGKURFCTUGRC-POYBYMJQSA-N |
| InChI | 1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1 |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥98% (HPLC) |
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