alpha1-Antitrypsin from human plasma, salt-free, lyophilized powder

alpha1-Antitrypsin from human plasma, salt-free, lyophilized powder

Biochem/physiol Actions

Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.

≤10 mg will inhibit 1.0 mg of trypsin with activity of 10,000 BAEE units per mg protein. ≤10 mg will inhibit approx. 1.0 mg of ·α-chymotrypsin with activity of 40-50 BTEE units per mg protein.

Caution

Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.

Packaging

25, 100, 500 mg in glass bottle

Preparation Note

Chromatographically prepared and partially purified.

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Code Description Quality Level Manufacturer Technique(s) Storage Temp. Form Assay Price Quantity
3586223 alpha1-Antitrypsin from human plasma, salt-free, lyophilized powder 200 SIGMA-ALDRICH inhibition assay: suitable 2-8°C salt-free, lyophilized powder ≥60% (biuret)
£1,073.50 (exc VAT) per 100MG
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3586224 alpha1-Antitrypsin from human plasma, salt-free, lyophilized powder 200 SIGMA-ALDRICH inhibition assay: suitable 2-8°C salt-free, lyophilized powder ≥60% (biuret)
£332.50 (exc VAT) per 25MG
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3586225 alpha1-Antitrypsin from human plasma, salt-free, lyophilized powder 200 SIGMA-ALDRICH inhibition assay: suitable 2-8°C salt-free, lyophilized powder ≥60% (biuret)
Click Add to Quote for price and delivery
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3586227 alpha1-Antitrypsin from human plasma, salt-free, lyophilized powder 200 SIGMA-ALDRICH - 2-8°C salt-free, lyophilized powder ≥70% protein basis (biuret)
Click Add to Quote for price and delivery
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3586228 alpha1-Antitrypsin from human plasma, salt-free, lyophilized powder 200 SIGMA-ALDRICH - 2-8°C salt-free, lyophilized powder ≥70% protein basis (biuret)
£342.00 (exc VAT) per 5MG
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