alpha1-Antitrypsin from human plasma, salt-free, lyophilized powder

alpha1-Antitrypsin from human plasma, salt-free, lyophilized powder

Stock Code: 3586228
Manufacturer Part No: A9024-5MG
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£342.00 (exc VAT) per 5MG
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Biochem/physiol Actions


1-4 mg will inhibit 1.0 mg of trypsin with activity of approx. 10,000 BAEE units per mg protein. 1-6 mg will inhibit 1.0 mg of α-chymotrypsin with activity of >=40 BTEE units per mg protein.


Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.


Caution


Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.


Packaging


5, 25 mg in glass bottle


Preparation Note


Chromatographically prepared and partially purified.

Quality Level200
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
Formsalt-free, lyophilized powder
Assay≥70% protein basis (biuret)

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