alpha1-Antitrypsin from human plasma, salt-free, lyophilized powder

alpha1-Antitrypsin from human plasma, salt-free, lyophilized powder

Stock Code: 3586225
Manufacturer Part No: A6150-500MG
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Biochem/physiol Actions


Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.


≤10 mg will inhibit 1.0 mg of trypsin with activity of 10,000 BAEE units per mg protein. ≤10 mg will inhibit approx. 1.0 mg of ·α-chymotrypsin with activity of 40-50 BTEE units per mg protein.


Caution


Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.


Packaging


25, 100, 500 mg in glass bottle


Preparation Note


Chromatographically prepared and partially purified.

Quality Level200
ManufacturerSIGMA-ALDRICH
Technique(s)inhibition assay: suitable
Storage Temp.2-8°C
Formsalt-free, lyophilized powder
Assay≥60% (biuret)

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