Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human, , >95% (SDS-PAGE), recombinan

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human, , >95% (SDS-PAGE), recombinan

Stock Code: 3593788
Manufacturer Part No: T7189-50UG
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Analysis Note

The biological activity is measured by its ability to neutralize the TNF-? mediated cytotoxicity in mouse L-929 cells in the presence of the metabolic inhibitor actinomycin D.

Application

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human can be used as a test compound for analyzing the interaction between tumor necrosis factor (TNF) and its two soluble receptors by using surface plasmon resonance (SPR) technique.

Biochem/physiol Actions

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human belongs to TNF family of receptors and mediates the metabolic effects of TNF-?. Tumor Necrosis Factor Soluble Receptor II blocks the TNF-?-induced apoptosis and hence regulates the TNF-? function. It also has a pivotal role in neutralizing the biological activities of both TNF-? and TNF-?.

Physical form

Lyophilized from a 0.2 µm filtered solution in phosphate buffered saline

ManufacturerSIGMA-ALDRICH
Impuritiesendotoxin, tested
Formlyophilized powder
Assay>95% (SDS-PAGE)

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