LAG-3 (mouse): FC (mouse), , recombinant, expressed in CHO cells, >95% (SDS-PAGE)

Stock Code: 3593624
Manufacturer Part No: SRP8041-50UG

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Descriptions

General description

Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

Other Notes

The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).

Physical form

Solution in PBS.