IL-1 Receptor Type I (human): FC (human), , recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

Stock Code: 3593615
Manufacturer Part No: SRP8032-50UG

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Descriptions

General description

IL-1RI is the receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappaB. Signaling involves formation of a ternary complex containing IL1RAP, leading the activation of TOLLIP, MYD88, and IRAK1 or IRAK2.

Other Notes

Human IL-1RI (interleukin-1 receptor type I) (aa 21-336) is fused at the C-terminus to the Fc portion of human IgG1.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 50 µL deionized water.