Fn14 (human): FC (human), , recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

Stock Code: 3593613
Manufacturer Part No: SRP8030-50UG

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Descriptions

General description

TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.

Other Notes

The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 50 µL deionized water.