DR6 (human): FC (human), , recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

Stock Code: 3593611
Manufacturer Part No: SRP8028-50UG

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Descriptions

General description

DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.

Other Notes

The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (aa 42-351).

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 50 µL deionized water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.