[Nle4, D-Phe7]-alpha-Melanocyte Stimulating Hormone trifluoroacetate salt, >=95% (HPLC)

Stock Code: 3591824
Manufacturer Part No: M8764-1MG

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Descriptions

Amino Acid Sequence

Ac-Ser-Tyr-Ser-Nle-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

Application

[Nle4, D-Phe7]-?-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice.1It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.

Biochem/physiol Actions

[Nle4, D-Phe7]-?-melanocyte stimulating hormone is 100 times more potent than ?-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as ?-MSH in S91adenylate cyclase assay. ? –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

General description

[Nle4, D-Phe7]-?-melanocyte stimulating hormone is a potent analogue of ?;-melanocyte-stimulating hormone (? -MSH). ?MSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.

Other Notes

Lyophilized from 0.1% TFA in H2O

Packaging

1 mg in glass bottle

Specifications

Quality Level	200
InChI key	BFGBZOSHJJSHTQ-CRYSLBJVSA-N
InChI	1S/C78H111N21O19.C2HF3O2/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)10
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥95% (HPLC)