[Lys-des-Arg9]-Bradykinin, >=95% (HPLC)

[Lys-des-Arg9]-Bradykinin, >=95% (HPLC)

Stock Code: 3589696
Manufacturer Part No: B1542-1MG
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Amino Acid Sequence

Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe

Application

[Lys-des-Arg9]-Bradykinin has been used as a B1R agonist to investigate the role of B1R in diabetes-induced secondary hemorrhage.

Biochem/physiol Actions

[Des-Arg10]-kallidin or [Lys-des-Arg9]-Bradykinin is a bradykinin B1 receptor agonist. It strongly upregulates the B1 receptor and is blocked by a specific protein kinase C inhibitor. The upregulation is correlated with the induction of transcription nuclear factor ?B (NF-?B). Elevation of Lys-des[Arg9]–bradykinin because of airway inflammation in asthma patients is known to modify the immune responses. It affects the migration and production of interleukin-12 in monocyte-derived dendritic cells.

Other Notes

Lyophilized from 0.1% TFA in H2O

Packaging

1 mg in glass bottle

Quality Level200
InChI keyAILVBOHFGXNHCC-TZPCGENMSA-N
InChI1S/C50H73N13O11/c51-22-8-7-17-33(52)42(66)58-34(18-9-23-55-50(53)54)46(70)63-26-12-21-40(63)48(72)62-25-10-19-38(62)44(68)56-29-41(65)57-35(27-31-13-3-1-4-14-3
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Formpowder
Assay≥95% (HPLC)

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