Apamin, synthetic, >=97% (HPLC)

Apamin, synthetic, >=97% (HPLC)

Stock Code: 3589659
Manufacturer Part No: A9459-.5MG
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Amino Acid Sequence

Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 [Disulfide Bridges: 1-11, 3-15]

Application

Apamin has been used in microbiological assays for the determination of antimicrobial activity of synthetic apamin and as a standard for MALDI (matrix-assisted laser desorption/ionization matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and electrospray ionisation mass spectrometry (ESI-MS) analysis.

Biochem/physiol Actions

Apamin is a neurotoxin which can pass the blood-brain barrier. In human, it might cause peripheral nerve dysfunction, mainly seen after bee stings.

The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.

General description

Apamin, a bee venom is a polypeptide, that is made of 18 amino acids with two disulfide bridges.

Other Notes

Lyophilized from 0.1% TFA in H2O

Quality Level200
InChI keyYVIIHEKJCKCXOB-STYWVVQQSA-N
InChI1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥97% (HPLC)

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