Autocamtide 2-related inhibitory peptide, >=97% (HPLC), lyophilized powder

Autocamtide 2-related inhibitory peptide, >=97% (HPLC), lyophilized powder

Stock Code: 3589529
Manufacturer Part No: A4308-1MG
Order Now for 7 day delivery
Click Add to Quote for price and delivery
Quantity: - +

Amino Acid Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Application

Autocamtide 2-related inhibitory peptide has been used:To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophagesTo study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice culturesTo quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII

Biochem/physiol Actions

Potent inhibitor of calmodulin-depentent protein kinase II.

Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels. Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C. Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction.

InChI keyCOEHZSYVSXUBHI-CYZNULJVSA-N
InChI1S/C65H114N20O21/c1-32(2)28-46(63(105)106)85-54(96)36(7)78-62(104)45(31-52(93)94)84-56(98)38(33(3)4)30-47(86)34(5)76-59(101)43(19-22-50(89)90)81-55(97)37(18-21
ManufacturerSIGMA-ALDRICH
CompositionPeptide content, ≥70%
Formlyophilized powder
Assay≥97% (HPLC)

There are no downloads for this product.