Asialofetuin from fetal calf serum, Type II (Sigma designation)

Asialofetuin from fetal calf serum, Type II (Sigma designation)

Stock Code: 3589438
Manufacturer Part No: A1908-50MG
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Application

Incorporation of asialofetuin (AF) in liposomes strongly enhance delivery to and endocytosis by cells displaying the AF receptor, notably hepatocytes. This provides a very efficient route for gene therapy.

Asialofetuin from fetal calf serum is suitable for use:in the assay of the lactose binding activity of the galectin-7 by immunodetection of in situ binding activity to asialofetuin immobilized on nitrocellulosein the inhibition of zona pellucida hardening of mouse oocytesas an acceptor in sialyltransferase enzyme activity assay

Biochem/physiol Actions

Feutins are glycoproteins that belong to the cystatin superfamily. They are characterized by the presence of two tandemly arranged cystatin-like domains and an unrelated domain. It binds to transforming growth factor (TGF)-?/BMP (bone morphogenic protein) cytokines.

Asialofetuin (AF) binds to asialoglycoprotein receptor (ASGP-R) and is employed as a ligand for drug delivery to the hepatocytes. It aids serum-resistant lipoplexes for efficient gene deliver into the HepG2 (human hepatoblastoma) cells.

Packaging

50 mg in poly bottle

Preparation Note

Enzymatic cleavage using neuraminidase

Quality Level200
ManufacturerSIGMA-ALDRICH
Technique(s)inhibition assay: suitable, activity assay: suitable
Storage Temp.2-8°C
Impuritiessalt, essentially free, ≤1.0% N-acetylneuraminic acid
SolubilityH2O: soluble 1.0 mg/mL, clear to hazy, colorless to very faintly yellow
Formpowder

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