N-Acetyl-5-hydroxytryptamine, >=99% (TLC), powder

N-Acetyl-5-hydroxytryptamine, >=99% (TLC), powder

Stock Code: 3589429
Manufacturer Part No: A1824-100MG
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Application

N-Acetyl-5-hydroxytryptamine has been used to treat neuron cells and to analyze its effects onKrüppel-like factor 15 (KLF15) expression.

Biochem/physiol Actions

Immediate precursor of melatonin. It is formed from serotonin and acetyl-CoA in a reaction catalyzed by serotonin N-acetyl transferase, the rate-limiting enzyme in melatonin biosynthesis. This indoleamine is a weak agonist at melatonin receptors, and has moderate effects on G-protein stimulation and inhibition of cAMP accumulation.

N-acetyl-serotonin (NAS/normelatonin) can act as a shelter to neurons due to its protecting ability against oxidative challenges. It can also repress the actions of the transcription factor NF-kappaB. NAS possesses antioxidant and antiaging actions. It has protective action against ?-amyloid induced neurotoxicity. It helps to maintain the optimal fluidity of the biological membranes.

General description

N-Acetylserotonin (NAS)/normelatonin acts as a precursor of melatonin in the tryptophan metabolic pathway.

Packaging

1 g in poly bottle

100 mg in poly bottle

Colourwhite to faint yellow
Quality Level200
mp120-122 °C (lit.)
InChI keyMVAWJSIDNICKHF-UHFFFAOYSA-N
InChI1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥99% (HPLC)

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