N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin, >=90% (HPLC), powder

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin, >=90% (HPLC), powder

Stock Code: 3589379
Manufacturer Part No: A0466-1MG
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Amino Acid Sequence

NAc-Asp-Glu-Val-Asp-AFC

Biochem/physiol Actions

A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. The 7-amido-4-trifluoromethylcoumarin derivative has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Colourwhite
Quality Level200
InChI keyGZDRODOYEFEHGG-NUDCOPPTSA-N
InChI1S/C30H34F3N5O13/c1-12(2)25(38-26(47)17(6-7-21(40)41)36-28(49)18(10-22(42)43)34-13(3)39)29(50)37-19(11-23(44)45)27(48)35-14-4-5-15-16(30(31,32)33)9-24(46)51-20
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥90% (HPLC)

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