Lectin from Triticum vulgaris, lyophilized, >=55% (GE), powder

Stock Code: 3589342
Manufacturer Part No: 61767-5MG

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Descriptions

Application

Lectin from Triticum vulgaris has been used in bone resorption assays.

Wheat germ agglutinin conjugated to the outside surface of PLGA nanoparticles loaded with paclitaxel was used to target cancer cells that overexpress WGA-binding glycoproteins (Caco-2 and HT-29 cell lines). WGA-NP showed 50-60% greater endocytosis and intracellular retention of paclitaxel than unlabeled nanoparticles.

Biochem/physiol Actions

Lectin is known to be useful in glycoconjugate characterizing, imaging and targeting. Its use in a microarray assay, enable efficient glycome profiling. This is because of its specific interaction with oligosaccharides, glycoproteins and glycolipids. In plants and fungi, lectin defends against pathogens/feeders. Lectin participates in host recognition and tissue adhesion, thereby aids in the pathogenesis of microorganism.

General description

Lectins are carbohydrate-binding proteins, omnipresent, found in fungi, plants and animals. The structure of lectin is diversely studied in plants and animals. The secondary structure of this protein is rich in ?-strands and posses a carbohydrate binding sites on the surface.

WGA is not blood group specific but has an affinity for N-acetyl-?-D-glucosaminyl residues and N-acetyl-?-D-glucosamine oligomers. WGA contains no protein-bound carbohydrate.

Other Notes

Molecular characteristics and specificity for sugar binding