Nodularin, cyanotoxin

Nodularin, cyanotoxin

Stock Code: 3577845
Manufacturer Part No: N5148-250UG
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Application


Nodularin has been used to induce oxidative stress and analyse its dynamics in flounder liver. It has also been used as standard for identification and quantification by high performance liquid chromatography (HPLC).


Biochem/physiol Actions


Potent inhibitor of protein phosphatases types 1 and 2A. Tumor promoter in experimental animal model.; at higher doses, causes massive liver hemorrhage. Tumor-promoting effect is due to increasing oxidative stress, as evidenced by reduced levels of glutathione and appearance of oxidative damage in DNA bases.


General description


Nodularin is a cyclic pentapeptide toxin produced by the cyanobacteria Nodularia spumigena.

Quality Level200
InChI keyIXBQSRWSVIBXNC-HSKGSTCASA-N
InChI1S/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)
ManufacturerSIGMA-ALDRICH
Solubilitymethanol: 2 mg/mL (Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.)
Formpowder
Assay≥94% (TLC)

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