Epoxomicin, >=95% (HPLC), solid

Epoxomicin, >=95% (HPLC), solid

Stock Code: 3577736
Manufacturer Part No: E3652-50UG
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Application


Epoxomicin has been used:as an ubiquitin–proteosome system (UPS) inhibitor in pheochromocytoma PC12 cellsas a proteasome inhibitor in mammary epithelial MCF-10A cellsas a proteasome inhibitor in chymotryptic assay in cardiomyocytes


Biochem/physiol Actions


Epoxomicin binds covalently to the catalytic subunits of proteasome. It forms an adduct with target proteins. It inhibits chymotrypsin-like activity of the proteasome. Epoxomicin also inhibits the nuclear factor ? light chain enhancer of activated B cells (NF-?B) mediated proinflammatory signalling pathway. It is also a potent antitumor and anti-inflammatory agent.


Epoxomicin, a natural product isolated from Actinomyces sp., is a cell-permeable, potent, selective and irreversible proteasome inhibitor.


General description


Epoxomicin is a linear peptide consisting of a threonine or serine residue with ??, ??-epoxyketonederived from leucine or a ?,?-dehydroleucine. It is a natural product isolated fromActinomycessp., and is a cell-permeable, potent, selective and irreversible proteasome inhibitor.


Packaging


50 µg in glass bottle

Quality Level100
InChI keyDOGIDQKFVLKMLQ-JTHVHQAWSA-N
InChI1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,33H,11-14H2,1-10H3,(
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Formsolid
Assay≥95% (HPLC)

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