Epoxomicin, >=95% (HPLC), solid
Application
Epoxomicin has been used:as an ubiquitin–proteosome system (UPS) inhibitor in pheochromocytoma PC12 cellsas a proteasome inhibitor in mammary epithelial MCF-10A cellsas a proteasome inhibitor in chymotryptic assay in cardiomyocytes
Biochem/physiol Actions
Epoxomicin binds covalently to the catalytic subunits of proteasome. It forms an adduct with target proteins. It inhibits chymotrypsin-like activity of the proteasome. Epoxomicin also inhibits the nuclear factor ? light chain enhancer of activated B cells (NF-?B) mediated proinflammatory signalling pathway. It is also a potent antitumor and anti-inflammatory agent.
Epoxomicin, a natural product isolated from Actinomyces sp., is a cell-permeable, potent, selective and irreversible proteasome inhibitor.
General description
Epoxomicin is a linear peptide consisting of a threonine or serine residue with ??, ??-epoxyketonederived from leucine or a ?,?-dehydroleucine. It is a natural product isolated fromActinomycessp., and is a cell-permeable, potent, selective and irreversible proteasome inhibitor.
Packaging
50 µg in glass bottle
| Quality Level | 100 |
|---|---|
| InChI key | DOGIDQKFVLKMLQ-JTHVHQAWSA-N |
| InChI | 1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,33H,11-14H2,1-10H3,( |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Form | solid |
| Assay | ≥95% (HPLC) |
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