Zardaverine, phosphodiesterase inhibitor
Application
Zardaverine has been used as a phosphodiesterase inhibitor:to study its effects on human colonic epithelial cellsto study its effects on junctional proteins in Sertoli cellsto study its effects on phosphodiesterase3A (PDE3A) expression in various tumor cells
Biochem/physiol Actions
Zardaverine is a derivative of pyridazinone. It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma.
Selective inhibitor of phosphodiesterase III/IV (PDE3/4).
| Quality Level | 200 |
|---|---|
| InChI key | HJMQDJPMQIHLPB-UHFFFAOYSA-N |
| InChI | 1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17) |
| Form | powder |
| Assay | ≥98% (HPLC) |
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