WKYMVM trifluoroacetate salt, >=98% (HPLC)

WKYMVM trifluoroacetate salt, >=98% (HPLC)

Stock Code: 3576996
Manufacturer Part No: W4270-1MG
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Amino Acid Sequence


Trp-Lys-Tyr-Met-Val-L-Met NH2


Application


WKYMVM trifluoroacetate salt was used as a test compound for investigating the mechanism of regulation of lipoprotein-associated phospholipase A2 (Lp-PLA2).


Biochem/physiol Actions


WKYMVM is a peptide agonist of formyl peptide receptors. WKYMVM binds to and stimulates FPRL family members 1, 2 with EC50 values of 2 and 80 nM, respectively. The peptide is a potent activator of neutrophils.


WKYMVM is an agonist and potent activator of Formyl peptide receptor like-1 (FPRL1). WKYMVM stimulates FPRL1 and hence attenuates the function of the chemokine receptors CCR5 and CXCR4. WKYMVM activates human eosinophils to induce superoxide production through Phosphoinositide 3-Kinase-Mediated ERK1/2 pathway.


Packaging


1 mg in glass bottle


Preparation Note


WKYMVM trifluoroacetate salt dissolves in water at a concentration >2 mg/mL to yield a clear solution.

Colourwhite to off-white
Quality Level100
InChI keyMYVYQWVNXDVTBW-CZPFDPCBSA-N
InChI1S/C41H61N9O7S2.C2HF3O2/c1-24(2)35(41(57)46-31(36(44)52)16-19-58-3)50-39(55)33(17-20-59-4)48-40(56)34(21-25-12-14-27(51)15-13-25)49-38(54)32(11-7-8-18-42)47-37
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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