PLATELET FACTOR -4

PLATELET FACTOR -4

Stock Code: 3576944
Manufacturer Part No: SRP3231-1MG
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Biochem/physiol Actions


PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the a-granules of platelets. Recombinant murine PF-4 is an 8.2 kDa protein containing 76 amino acid residues, including the four highly conserved residues present in CXC chemokines.


General description


PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the a-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant murine PF-4 is an 8.2 kDa protein containing 76 amino acid residues, including the four highly conserved residues present in CXC chemokines.


Physical form


Lyophilized with no additives.


Reconstitution


Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.


Sequence


VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES

Colourwhite
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Impurities≤0.1 EU/µg endotoxin, tested
Formlyophilized
Assay≥98% (SDS-PAGE); ≥98% (HPLC)

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