PLATELET FACTOR 4

PLATELET FACTOR 4

Stock Code: 3576943
Manufacturer Part No: SRP3142-1MG
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Biochem/physiol Actions


Platelet factor-4 (PF-4) is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. This protein associates with heparin and neutralizes it. It also neutralizes various negatively charged proteoglycans.


General description


Platelet factor-4 (PF-4) is a CXC chemokine that is expressed in megakaryocytes and stored in the alpha-granules of platelets. The gene encoding this protein is localized on human chromosome 4. Recombinant human PF-4 is a 7.8kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.


Physical form


Lyophilized with no additives.


Reconstitution


Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.


Sequence


EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES

Colourwhite
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Impurities≤0.1 EU/µg endotoxin, tested
Formlyophilized
Assay≥98% (SDS-PAGE); ≥98% (HPLC)

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