LYS6K2

Stock Code: 3576908
Manufacturer Part No: SRP0703-25MG

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Descriptions

Biochem/physiol Actions

A selective inhibitor of the p70 ribosomal S6 kinase (S6K). Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 uM with no activity at GSK3beta and Erk1/2 at 10 uM ⁽²⁾. Useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K. Cell permeable.

Reconstitution

Formulated as a lyophilized powder. May be dissolved in DMSO (1 mg/mL) or DMF (3 mg/mL, warm).

Storage and Stability

Store desiccated as supplied at -20°C for up to 3 years. Store solutions at -20°C for up to 3 months.