ML167

ML167

Stock Code: 3574252
Manufacturer Part No: SML0924-5MG
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Biochem/physiol Actions


ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B, and minimal activity against a panel of other kinases tested. The Cdc2-like kinases (Clk’;s) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk’;s) are involved in regulation of gene splicing. The Cdc2-like kinases phosphorylate the serine/arginine-rich (SR) proteins, a major component of the spliceosome.


Packaging


5, 25 mg in glass bottle

Colouroff-white to gray-brown
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 10 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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