TAPI-2 acetate salt, >=98% (HPLC)

TAPI-2 acetate salt, >=98% (HPLC)

Stock Code: 3574078
Manufacturer Part No: SML0420-1MG
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Application


TAPI-2 acetate salt has been used to inhibit protease activity in HepG2 cells.


Biochem/physiol Actions


TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-A convertase/ADAM17/A-secretase). It blocks the shedding of several cell surface proteins such as β-amyloid precursor protein, inhibits TNF-A release as well as a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands. TAPI-2 is considered a fairly broad metalloproteinase inhibitor, but it much more selective for TACE than GM6001.


Features and Benefits


This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Packaging


1 mg in glass bottle

Colourwhite to off-white
Quality Level100
InChI keyLMUSZKBIFGOFBD-RAFLFFCLSA-N
InChI1S/C19H37N5O5.C2H4O2/c1-11(2)9-13(10-14(25)24-29)17(27)23-15(19(4,5)6)18(28)22-12(3)16(26)21-8-7-20;1-2(3)4/h11-13,15,29H,7-10,20H2,1-6H3,(H,21,26)(H,22,28)(H,
ManufacturerSIGMA-ALDRICH
Formlyophilized powder
Assay≥98% (HPLC)

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