Eicosapentaenoyl ethanolamide, 5 mg/mL in absolute ethanol, >=98% (HPLC)

Eicosapentaenoyl ethanolamide, 5 mg/mL in absolute ethanol, >=98% (HPLC)

Stock Code: 3574056
Manufacturer Part No: SML0384-5MG
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Biochem/physiol Actions


Eicosapentaenoyl ethanolamide (EPEA) is a lipid mediator that has been found to suppress lifespan extension resulting from dietary restriction in C. elegans and also to have antiproliferative and anti-inflammatory actions. In C. elegans, it is believed to act as a metabolic signal that couples nutrient availability with growth and lifespan. EPEA is a member of the N-acylethanolamines (NAEs), lipid-derived signaling molecules that include the mammalian endocannabinoid arachidonoyl ethanolamide (AEA). In mammals, NAEs are believed to act primarily through cannabinoid receptors, although they can also interact with a variety of other targets, and EPEA has been shown to act as a CB1 and CB2 receptor agonist. However, C. elegans does not possess clear orthologues of the mammalian cannabinoid receptors which suggests that there are unidentified NAE receptors in nematodes that are possibly conserved mediators of NAE signaling.


Other Notes


Light and air sensitive; store in a freezer.


Packaging


5, 25 mg in glass bottle

Colourlight yellow
Quality Level100
InChI keyOVKKNJPJQKTXIT-JLNKQSITSA-N
InChI1S/C22H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h3-4,6-7,9-10,12-13,15-16,24H,2,5,8,11,14,17-21H2,1H3,(H,23,25)/b4-3-,7-6-,10-9
ManufacturerSIGMA-ALDRICH
Formsolution
Assay≥98% (HPLC)

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